Journal article
Formation of Polyrotaxane Particles via Template Assembly
BL Tardy, S Tan, HH Dam, T Suma, J Guo, GG Qiao, F Caruso
Biomacromolecules | AMER CHEMICAL SOC | Published : 2017
Abstract
In this study, we report a versatile method to assemble tunable poly(ethylene glycol) (PEG)-based polyrotaxane (PRX) particles and capsules. By threading α-cyclodextrins (αCDs) onto PEG chains physically adsorbed onto template particles and subsequently dissolving the templates, PRX replica particles and hollow capsules are formed. This approach overcomes issues related to CD steric hindrance, and also reduces the multiple processing steps often associated with PRX-based particle formation. By simple variation of the molecular weight and end-group functionality of the PEG, we show that the rate of particle degradation as well as the stability of the particles can be tuned. We also demonstrat..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
This research was in part conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036), and the ARC under the Australian Laureate Fellowship (FL120100030, F.C) scheme. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). The authors would like to thank Dr. Yi Ju for assistance with particle preparation, and Farshad Motevalizadeh for assistance with TGA